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The Helix3 team has been consistently working together since 1994 developing new methods and conducting GLP studies for regulatory submissions.  We are committed to providing innovative solutions with an unmatched focus on quality, flexibility and attention to detail.


Reducing risk of false positives in the in vivo

comet assay and improving result reliability

(Mutation Research 2024)

Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay

(Environmental and Mol. Mut. 2024)

In vivo genotoxicity testing strategies:  Report from the 8th International Workshop on Genotoxicity Testing (IWGT)

(Environmental and Mol. Mut. 2024)

Measuring DNA modifications with the comet assay:  a compendium of protocols

(Nature Protocols 2023)

Genetic Toxicology Tesing-A Laboratory Manual  Chapter 10:  The In Vivo Comet Assay (Elsevier 2016)

Critical issues with the comet assay:  A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT) (Mutation Research 2015)

Recommendations for Safety Testing with the in vivo comet assay (Mutation Research 2012)

Combining the in vivo comet and micronucleus assays:  A practical approach to genotoxicity testing and data interpretation (Mutagenesis 2010)

The comet assay as an indicator test for germ cell genoxocity testing (Mutation Research 2009)


Technical issues influencing in vivo comet results (IWGT 2023)

The Comet Assay and the Helix3 Difference


Cytotoxicity and its impact on the in vivo comet assay (IWGT 2013)

Evaluating DNA reactivity with the acellular comet assay (GTA 2011)

The comet assay:  Breaking from tradition (GTA 2008)

Target organ selection for the in vivo comet assay:  Genotoxicity vs. tumorigenesis (EMS 2008)

Safety testing with the in vitro comet assay:  Critital factors in protocol design and data interpretation (EMS 2007)

The effects of sample processing on in vivo comet assay samples (EMS 2006)

Fourth International Workgroup on Genotoxicity Testing:  Results of the in vivo comet assay workgroup

(Mutation Research 2007)

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